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GENOMICS PROTEOMICS

Olink Technology

This is a proteonomics analysis technique based on Biomark HD hardware solutions and Olink diagnostic kits.

It enables protein analyses performed using antibody kits labeled with DNA sequences. The technology uses tissue material, blood and body fluids, as well as those derived from cell cultures.

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Currently, analytical panels dedicated to the following areas are available:
Mouse:

  • 88 marker screening panel

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Panels dedicated to humans:

  • Cytokine panel - 48 markers

  • Neurology panel - 96 markers

  • Oncology panel - 96 markers

  • Organ damage panel - 96 markers

  • Metabolic panel - 96 markers

  • Cell regulation panel - 96 markers

Technology Biomark HD

This is a high-throughput genomic and proteomic analysis technology based on integrated fluidic circuits (IFCs) solutions.


It enables the automation of molecular biology analyses in nanoliter volumes.

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The use of nanoliter volumes for assays, reduces sample volume, the amount of reagents consumed, significantly shortens the time of analyses performed, and makes it possible to obtain consistent analyses of complex panels of genetic and protein markers.

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General applications:

  • Gene expression analyses

  • Genotyping

  • Digital PCR

  • Sample identification

  • Quantitative protein analysis - Olink-based proteomic analysis

  • The technology is based on the same assumptions as PCR, so it works with a wide range of chemistries and primers/probes

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Advantages of Biomark HD technology:

  • Ability to simultaneously analyze up to 192 genetic markers

  • Minimal amount of material needed

  • Ability to procedure different types of biological material

  • Internal validation of the test between individual markers

 

The customer can use:

  • ALAB bioscience developed diagnostic profiles

  • Can modify and adapt them to his own needs

  • May ask for the development of an individual diagnostic package

  • Can develop a marker profile on their own and have it performed

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The customer can use:​

  • Diagnostic profiles developed by ALAB bioscience

  • Possibility of modification and customization

  • Ability to develop an individual diagnostic package

  • Possibility to develop marker profiles on their own and have them performed

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Diagnostic profiles for in vivo and in vitro mouse and human samples:

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                                                                   Oncology                       Neurology                      Screening

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                                                              Cardiology                       Diabetes                                p53

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                                                            Cell Cycle                     Inflammation        Transcription Factors

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                                                           Angiogenesis             Breast cancer               Melanogenesis  

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Individual development of diagnostic profiles for:

  • Identification of various infectious pathogens

  • Identification of genetic variants of a single pathogen

  • Genotyping of single-gene traits

  • Identification of race and ancestry

  • Identification of genetic diseases

  • Transcriptomic evaluation of the expression of complex gene panels

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Chromatography and spectrometry

  • Measurement of protein and peptide mass

  • Identification of proteins and peptides

  • Identification and localization of post-translational modifications

  • Comparative analyzes of proteomes

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Sequencing

In our laboratory, we perform transcriptomic testing based on NGS technology targeting both individual clients and preclinical studies.

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As part of the research, we perform:

  • Isolation of genetic material with its qualitative analysis

  • Sequencing of the microbiome

  • Whole-genome sequencing

  • Whole-exome sequencing

  • Total RNA-Seq analysis

  • Bioinformatics analysis of the results

 

In addition, we offer the use of our personalized diagnostic panels:

  • Oncological

  • Genetic burdens

  • Screening tests

  • Whole-genome

  • ACMG

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